Taylor & Francis, Inc. 2010-04-02 ISBN: 0815341490 807 pages PDF 259 MB

Human Molecular Genetics is an established and class-proven book for upper-level undergraduates and graduate students which provides an authoritative and integd approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.

The has been restructured so genomic technologies are integd throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

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Nova Science Publishers, Incorpod 2011-03-30 ISBN: 1616680067 336 pages PDF 2,9 MB

Metabolomics is the logical progression of the study of genes, transcripts and proteins. Nutrients, gut microbial metabolites and other bioactive food constituents interact with the body at system, organ, cellular and molecular levels, and effect the expression of genome at several levels, and subsequently, the production of metabolites. This book presents an overview of nutrigenomics and metabolomics tools, and their perspective in livestock health and production. In addition, this book describes how lists of masses (molecular ions) and mass unit bins of interest are searched within online databases for compound identification, the extra biochemical data required for metabolite confirmation, how data are visualised and what the putative and protein sequences are associated with observed metabolic changes. Moreover, environmental metabolomics is the application of metabolomics to the investigation of both free-living organisms directly obtained from the natural environment or laboratory conditions. This book outlines some of the advances made in areas of plant environmental metabolomics. The applications of microbial metagenomics, the use of genomics techniques to the study of communities of directly in their diverse natural environments, are explored as well. Other chapters examine the abnormalities in metabolism of cancer cells, which could play a stgic role in tumour initiation and behaviour.

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Churchill Livingstone; 13 edition July 9, 2007 ISBN-10: 0702029173 436 pages PDF 37.16 MB

Emery’s Elements of Medical Genetics has been a best seller for over 30 years. Generations of students have appreciated its unique balance of basic science…genetics as applied to medicine…and clinical genetics. With its rigorously updated content and STUDENT CONSULT access, the 13th Edition of this classic delivers even more learning opportunities! Clinical examples, improved clinical photographs, and multiple-choice and case-based review questions make state-of-the-art knowledge easier to learn than ever before. When you combine all of these enhancements with the succinct, straightforward, well-illustd coverage that readers have always enjoyed, the result is a superb resource that helps you master the genetics you need to know.
• Better understand and apply basic principles of genetics to clinical situations.
• Quickly review key clinical knowledge with handy summary boxes.
• Know where to find further information online with a section dedicated to internet research.
• Test your knowledge with multiple-choice and case-based questions.

• Tap into the latest developments with new chapters on ophthalmic genetics, skeletal dysplasias, stem cell therapy, and genetics and the law.
• Stay informed with updated chapters on all aspects of genetics, from DNA technology and applications, developmental genetics, and polygenic and multifactorial inheritance through to pharmacogenetics, cancer genetics, and congenital abnormalities.
• Identify the genetic factors behind common with a newly revised chapter dedicated solely to this important subject.
• See rare genetic disorders in stunning detail with improved clinical photographs.

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Ac..mic Press 2010 ISBN: 0123334454 600 pages PDF 30,7 MB

As genetic issues play a growing role in health practice and public policy, new knowledge in this field will continue to have significant implications for individuals and society.

Written to communicate sound and modern science in an accessible way for professionals and students with various levels of scientific background, this thoroughly revised edition of The Human Genome contributes to creating a genetically lite research and clinical population. With case studies and introductory vignettes which illust a wide range of perspectives on complex topics in genetics and updated material on the latest research on disease-specific topics, this book serves as a valuable resource for students and working professionals alike.

* -color illustrations enhance and reinforce key concepts and themes
* Chapters include interest boxes that focus on human health and disease, chapter-opening case studies, and concept s to engage non-specialist readers
* Companion website includes self tests, electronic artwork, and a guide to additional web resources to meet the developing needs of health care professionals and researchers

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Springer 2011 ISBN: 1848826435 353 pages PDF 7,4 MB

Epigenetic Aspects of Chronic assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written widely published experts, Epigenetic Aspects of Chronic is a valuable reference tool for clinicians and researchers who investigate and treat chronic , as well as health care personnel, post-doctoral fellows and medical or dental students.

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Publisher: CRC Press English ISBN-10: 084938768X October 6, 2008 PDF 1154 pages 36.19 mb

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Stgies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Stgies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic stgies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic stgies. The middle section focuses on gene expression and detection, followed an examination of various therapeutic stgies for individual , including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

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