Cells, Aging, and Human Disease

Publisher: Oxford University Press, USA
Number Of Pages: 504
Publication Date: 2004-06-10
ISBN-10 / ASIN: 0195140354
ISBN-13 / EAN: 9780195140354
Binding: Hardcover

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age- disease. With over 4,000 references, this explores both the fundamental processes of human aging and the tissue–tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age- disease.
Far from merely sharing a common onset late in the lifespan, age- are linked fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence–and the general model–cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.
The second edition, oriented organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes–the progerias–the reviews aging (Alzheimer’s dementia, osteoarthritis, atherosclerosis, immune aging, presopia, sarcopenia, etc.) in the con of the tissues in which they occur. Each of the ten clinical chapters–skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes–examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

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