Kidney and Blood Pressure Regulation
Sepsis, Kidney and Multiple Organ Dysfunction (Contributions to Nephrology)
Claudio Ronco, Rinaldo Bellomo, Alessandra Brendolan
Publisher: S Karger Pub
Number Of Pages: 403
Publication Date: 2004-05-10
ISBN-10 / ASIN: 3805577516
ISBN-13 / EAN: 9783805577519
Binding: Hardcover
Product Description:
Chronic kidney disease is one of the world’s major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular back. This book reviews experimental data which form the basis of our current understanding of the association between hypertension and kidney : The pathogenesis of increased blood pressure, the mechanisms which systemic hypertension promotes progressive kidney failure, and the impact of antihypertensive agents on experimental renal mechanisms involved in hypertension. Furthermore, the role of angiotensin II receptor blockers in both the control of systemic blood pressure and the reduction of proteinuria is examined in an attempt to define optimal therapeutic stgies to prevent the otherwise inexorable deterioration of renal function in patients with chronic kidney disease.
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